Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe

Article Article scientifique Article Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe eng 1977-11-01 author Decorzant Christiane author Riondel Anne-Marie 47414 author Lob Philippe Sabine Marie Joséphe 88300 author Bertrand Jean 25466 author Vallotton Michel 25057 423-430 10.1042/cs0530423 589927 0301-0538 https://portlandpress.com/clinsci/article/53/5/423/70950/Detection-of-Na-and-K-in-the-Rat-Adrenal-Cortex 1. In order to demonstrate whether modification of aldosterone secretion is mediated by parallel changes of K⁺ in the adrenal zona glomerulosa, the total (intracellular + extracellular) Na⁺ and K⁺ content of the rat adrenal cortex was determined with the electron microprobe. 2. Groups of rats were submitted to one of the following dietary regimens: standard, low Na⁺, high K⁺ or high Na⁺. 3. Distribution of Na⁺ and K⁺ across the zona glomerulosa and zona fasciculata was compared. Standards of known electrolyte concentration were also analysed. 4. The [Na⁺] was found to be greater in the zona glomerulosa than in the zona fasciculata but K⁺ was distributed evenly in both zones. This was independent of dietary regimen. 5. Aldosterone production, assessed by plasma aldosterone concentrations, could not be correlated with zona glomerulosa K⁺ content. Adrenal Cortex / analysis* Aldosterone / blood Animals Corticosterone / blood Electron Probe Microanalysis Male Potassium / analysis* Rats Sodium / analysis* Dewey 550 141 Département de minéralogie 152 42 Département des sciences de la Terre 154 false Clinical science and molecular medicine 53 5 e3ad3763-0a10-44ab-a1ed-754fd26d409e Article (Published version) Restricted Decorzant_CSMM_197753423.pdf 3972341 application/pdf restrictedAccess Faculté des sciences / Section des sciences de la Terre et de l'Environnement / Département de minéralogie Faculté des sciences / Section des sciences de la Terre et de l'Environnement / Département des sciences de la Terre

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Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe	Clinical science and molecular medicine			1977	159	0

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Lob Philippe, Sabine Marie Joséphe