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Title

SARS-CoV-2 antibody seroprevalence and associated risk factors in an urban district in Cameroon

Authors
Fokam, Joseph
Wanda, Franck
Mama, Lucien
Meke, Jeanine
Tassegning, Armel
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Published in Nature communications. 2021, vol. 12, 5851
Abstract The extent of SARS-CoV-2 circulation in many African countries remains unclear, underlining the need for antibody sero-surveys to assess the cumulative attack rate. Here, we present the results of a cross-sectional sero-survey of a random sample of residents of a health district in Yaounde, Cameroon, conducted from October 14 to November 26, 2020. Among the 971 participants, the test-adjusted seroprevalence of anti-SARS-CoV-2 IgG antibodies was 29·2% (95% CI 24·3–34·1). This is about 322 times greater than the 0.09% nationwide attack rate implied by COVID-19 case counts at the time. Men, obese individuals and those living in large households were significantly more likely to be seropositive, and the majority (64·2% [58·7–69·4]) of seropositive individuals reported no symptoms. Despite the high seroprevalence, most of the population had not been infected with SARS-CoV-2, highlighting the importance of continued measures to control viral spread and quick vaccine deployment to protect the vulnerable.
Keywords COVID19SARS-COV-2AfricaCameroonYaoundeSeroprevalence
Identifiers
PMID: 34615863
PMCID: PMC8494753
Full text
Article (Published version) (2.2 MB) - public document Free access
Appendix (1.4 MB) - public document Free access
Dataset: https://doi.org/10.5281/zenodo.5218965
Structures
Research groups TIGERS
ISE Pôle Informatique environnementale
GeoHealth: approches géospatiales et environnementales en santé globale (1000)
Maladies infectieuses et modèles mathématiques (988)
Projects
Swiss National Science Foundation: PP00P3_163878
Swiss National Science Foundation: 31CA30_196270
Citation
(ISO format)
NWOSU, Kenechukwu et al. SARS-CoV-2 antibody seroprevalence and associated risk factors in an urban district in Cameroon. In: Nature communications, 2021, vol. 12, p. 5851. doi: 10.1038/s41467-021-25946-0 https://archive-ouverte.unige.ch/unige:155304

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Deposited on : 2021-10-12

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