The aim of this study was to investigate the effects of saliva contamination and the cleaning of the bond surface of titanium base (ti-base) abutments on the bonding stability and retention force values. The bond surface of the ti-base abutments was treated with airborne-particle abrasion. After contamination, the ti-base abutments underwent different cleaning protocols: water spray (H2O); alcohol (ALC); suspension of zirconium particles (SZP); reapplied airborne-particle abrasion (APA); and a control condition without contamination and cleaning (CTR). All lithium disilicate crowns were bonded to the ti-base abutments using a primer and a self-curing composite. Bonded specimens underwent thermo-mechanical aging. Bond failure analysis and pull-off testing were performed. Bond failure occurred more frequently in groups H2O, ALC, SZP, and APA (p < 0.05). Significant differences in retention force values were only found between CTR and ALC (p < 0.05). Specimens which did not show bond failure after ageing had higher retention force values than the specimens that showed bond failure (p < 0.05). Saliva contamination with cleaning can degrade the bonding properties to titanium. For the retention force values, only the protocol with alcohol after contamination could not restore the values.