In recent decades, landslide disasters in the Himalayas, as in other mountain regions, are widely reported to have increased. While some studies have suggested a link to increasing heavy rainfall under a warmer climate, others pointed to anthropogenic influences on slope stability, and increasing exposure of people and assets located in harm's way. A lack of sufficiently high-resolution regional landslide inventories, both spatially and temporally, has prevented any robust consensus so far. Focusing on Far-Western Nepal, we draw on remote sensing techniques to create a regional inventory of 26,350 single landslide events, of which 8778 date to the period 1992–2018. These events serve as a basis for the analyses of landslide frequency relationships and trends in relation to precipitation and temperature datasets. Results show a strong correlation between the annual number of shallow landslides and the accumulated monsoon precipitation (r = 0.74). Furthermore, warm and dry monsoons followed by especially rainy monsoons produce the highest incidence of shallow landslides (r = 0.77). However, we find strong spatial variability in the strength of these relationships, which is linked to recent demographic development in the region. This highlights the role of anthropogenic drivers, and in particular road cutting and land-use change, in amplifying the seasonal monsoon influence on slope stability. In parallel, the absence of any long-term trends in landslide activity, despite widely reported increase in landslide disasters, points strongly to increasing exposure of people and infrastructure as the main driver of landslide disasters in this region of Nepal. By contrast, no climate change signal is evident from the data.