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Title

Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

Authors
Melton, D A
Published in Nature. 1989, vol. 341, no. 6237, p. 33-38
Abstract The expression of the Xenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. Different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. These factors and homoeobox genes thus form part of the mechanism necessary for establishing antero-posterior polarity in the frog embryo.
Keywords AnimalsCell DifferentiationEmbryonic InductionGene Expression RegulationGenesHomeoboxGrowth Substances/physiologyMesoderm/physiologyMorphogenesisRNAMessenger/geneticsXenopus laevis/embryology
Identifiers
PMID: 2570357
Full text
Article (Published version) (9.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Stemness dans le développement et les maladies: Signalisation, reprogrammation et mécanismes des métastases (776)
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(ISO format)
RUIZ ALTABA, Ariel, MELTON, D A. Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. In: Nature, 1989, vol. 341, n° 6237, p. 33-38. doi: 10.1038/341033a0 https://archive-ouverte.unige.ch/unige:154191

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