en
Scientific article
Letter
English

Gli/Zic factors pattern the neural plate by defining domains of cell differentiation

Published inNature, vol. 393, no. 6685, p. 579-583
Publication date1998
Abstract

Three cell types differentiate in the early frog neural plate: neural crest at the lateral edges, floorplate at the midline and primary neurons in three bilateral stripes. Floorplate cells and ventral neurons are induced by Sonic hedgehog (Shh) and neural crest and dorsal neurons are induced by epidermal factors such as bone morphogenetic proteins (BMPs). Neurogenesis in a subset of cells within the stripes involves lateral inhibition. However, the process by which pools of precursors are defined in stereotypic domains in response to inductive signals is unknown. Here we show that frog Zic2 encodes a zinc-finger transcription factor of the Gli superfamily which is expressed in stripes that alternate with those in which primary neurons differentiate and overlap the domains of floorplate and neural crest progenitors. Zic2 inhibits neurogenesis and induces neural crest differentiation. Conversely, Gli proteins are widely expressed, induce neurogenesis and inhibit neural crest differentiation. Zic2 is therefore a vertebrate pre-pattern gene, encoding anti-neurogenic and crest-inducing functions that counteract the neurogenic but not the floorplate-inducing activity of Gli proteins. We propose that the combined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell differentiation.

Keywords
  • Animals
  • Body Patterning
  • Cell Differentiation
  • Drosophila
  • Embryonic Induction
  • Molecular Sequence Data
  • Nerve Tissue Proteins/biosynthesis
  • Neural Cell Adhesion Molecules/biosynthesis
  • Neural Crest/cytology/embryology
  • Neurons/cytology
  • Oncogene Proteins/genetics/physiology
  • Recombinant Fusion Proteins/genetics
  • Trans-Activators
  • Transcription Factors/genetics/physiology
  • Tubulin/biosynthesis
  • Xenopus Proteins
  • Xenopus laevis
  • Zinc Finger Protein GLI1
  • Zinc Fingers
Affiliation Not a UNIGE publication
Citation (ISO format)
BREWSTER, R, LEE, J, RUIZ ALTABA, Ariel. Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. In: Nature, 1998, vol. 393, n° 6685, p. 579–583. doi: 10.1038/31242
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0028-0836
91views
0downloads

Technical informations

Creation08/16/2021 3:08:00 PM
First validation08/16/2021 3:08:00 PM
Update time03/16/2023 1:08:36 AM
Status update03/16/2023 1:08:36 AM
Last indexation01/17/2024 2:01:49 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack