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Common TLR5 mutations control cancer progression

Publié dansCancer Cell, vol. 27, no. 1, p. 1-3
Date de publication2015
Résumé

The mechanisms regulating tumor-associated inflammation are incompletely understood. In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate extraintestinal cancers.

Mots-clés
  • Animals
  • Humans
  • Interleukin-17/metabolism
  • Interleukin-6/metabolism
  • Microbiota
  • Neoplasms/immunology/pathology
  • Toll-Like Receptor 5/genetics/metabolism
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
PFIRSCHKE, Christina, GARRIS, Christopher, PITTET, Mikaël. Common TLR5 mutations control cancer progression. In: Cancer Cell, 2015, vol. 27, n° 1, p. 1–3. doi: 10.1016/j.ccell.2014.12.008
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Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal1535-6108
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Informations techniques

Création08/07/2021 17:43:00
Première validation08/07/2021 17:43:00
Heure de mise à jour16/03/2023 01:06:38
Changement de statut16/03/2023 01:06:38
Dernière indexation17/01/2024 13:59:08
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