ER stress in dendritic cells promotes cancer

Garris, Christopher S; Pittet, Mikaël

doi:10.1016/j.cell.2015.06.006

Scientific article

Comment

English

ER stress in dendritic cells promotes cancer

ContributorsGarris, Christopher S; Pittet, Mikaël

Published inCell, vol. 161, no. 7, p. 1492-1493

Publication date2015

Abstract

XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy.

Keywords

Animals
DNA-Binding Proteins/metabolism
Dendritic Cells/pathology
Endoplasmic Reticulum Stress
Female
Humans
Ovarian Neoplasms/immunology/pathology
Transcription Factors/metabolism

Affiliation entities

Not a UNIGE publication

Research groups

Comprendre et manipuler le système immunitaire pour lutter contre le cancer (1024)

Citation (ISO format)

GARRIS, Christopher S, PITTET, Mikaël. ER stress in dendritic cells promotes cancer. In: Cell, 2015, vol. 161, n° 7, p. 1492–1493. doi: 10.1016/j.cell.2015.06.006

Article (Published version)

Identifiers

PID : unige:154071
DOI : 10.1016/j.cell.2015.06.006
PMID : 26091029

Journal ISSN0092-8674

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ER stress in dendritic cells promotes cancer

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