Scientific Article
previous document  unige:154063  next document
add to browser collection
Title

Neutrophils suppress intraluminal NK cell-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells

Authors
Spiegel, Asaf
Brooks, Mary W
Houshyar, Samin
Reinhardt, Ferenc
Ardolino, Michele
Fessler, Evelyn
Chen, Michelle B
Krall, Jordan A
show hidden authors show all authors [1 - 17]
Published in Cancer Discovery. 2016, vol. 6, no. 6, p. 630-649
Abstract Immune cells promote the initial metastatic dissemination of carcinoma cells from primary tumors. In contrast to their well-studied functions in the initial stages of metastasis, the specific roles of immunocytes in facilitating progression through the critical later steps of the invasion-metastasis cascade remain poorly understood. Here, we define novel functions of neutrophils in promoting intraluminal survival and extravasation at sites of metastatic dissemination. We show that CD11b(+)/Ly6G(+) neutrophils enhance metastasis formation via two distinct mechanisms. First, neutrophils inhibit natural killer cell function, which leads to a significant increase in the intraluminal survival time of tumor cells. Thereafter, neutrophils operate to facilitate extravasation of tumor cells through the secretion of IL1β and matrix metalloproteinases. These results identify neutrophils as key regulators of intraluminal survival and extravasation through their cross-talk with host cells and disseminating carcinoma cells.
Keywords Adoptive TransferAnimalsBiomarkersCarcinoma/genetics/immunology/metabolism/pathologyCell CommunicationCell LineTumorCell MovementCell SurvivalCytokines/biosynthesisDisease ModelsAnimalEndothelial Cells/metabolismHeterograftsHumansImmunityInnateImmunophenotypingKiller CellsNatural/immunology/metabolismMatrix Metalloproteinases/metabolismMiceMiceKnockoutNeoplasm InvasivenessNeoplasm MetastasisNeutrophils/immunology/metabolismPhenotype
Identifiers
PMID: 27072748
Full text
Research group Groupe Mikael Pittet (1024)
Citation
(ISO format)
SPIEGEL, Asaf et al. Neutrophils suppress intraluminal NK cell-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells. In: Cancer Discovery, 2016, vol. 6, n° 6, p. 630-649. doi: 10.1158/2159-8290.CD-15-1157 https://archive-ouverte.unige.ch/unige:154063

23 hits

10 downloads

Update

Deposited on : 2021-08-24

Export document
Format :
Citation style :