en
Scientific article
Review
English

The role of myeloid cells in cancer therapies

Published inNature Reviews Cancer, vol. 16, no. 7, p. 447-462
Publication date2016
Abstract

Recent clinical trials have demonstrated the ability to durably control cancer in some patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer treatment but benefit only a minority of patients. It is thus a crucial time for clinicians, cancer scientists and immunologists to determine the next steps in shifting cancer treatment towards better cancer control. This Review describes recent advances in our understanding of tumour-associated myeloid cells. These cells remain less studied than T lymphocytes but have attracted particular attention because their presence in tumours is often linked to altered patient survival. Also, experimental studies indicate that myeloid cells modulate key cancer-associated activities, including immune evasion, and affect virtually all types of cancer therapy. Consequently, targeting myeloid cells could overcome limitations of current treatment options.

Keywords
  • Humans
  • Immunity
  • Innate
  • Immunotherapy
  • Myeloid Cells/cytology
  • Neoplasms/immunology/therapy
  • Tumor Microenvironment
Affiliation Not a UNIGE publication
Citation (ISO format)
ENGBLOM, Camilla, PFIRSCHKE, Christina, PITTET, Mikaël. The role of myeloid cells in cancer therapies. In: Nature Reviews Cancer, 2016, vol. 16, n° 7, p. 447–462. doi: 10.1038/nrc.2016.54
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Article (Published version)
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ISSN of the journal1474-175X
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