en
Scientific article
Open access
English

Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenge

Published inImmunity, vol. 51, no. 5, p. 899-914.e7
Publication date2019
Abstract

Myocardial infarction, stroke, and sepsis trigger systemic inflammation and organism-wide complications that are difficult to manage. Here, we examined the contribution of macrophages residing in vital organs to the systemic response after these injuries. We generated a comprehensive catalog of changes in macrophage number, origin, and gene expression in the heart, brain, liver, kidney, and lung of mice with myocardial infarction, stroke, or sepsis. Predominantly fueled by heightened local proliferation, tissue macrophage numbers increased systemically. Macrophages in the same organ responded similarly to different injuries by altering expression of tissue-specific gene sets. Preceding myocardial infarction improved survival of subsequent pneumonia due to enhanced bacterial clearance, which was caused by IFNɣ priming of alveolar macrophages. Conversely, EGF receptor signaling in macrophages exacerbated inflammatory lung injury. Our data suggest that local injury activates macrophages in remote organs and that targeting macrophages could improve resilience against systemic complications following myocardial infarction, stroke, and sepsis.

Keywords
  • Animals
  • Biomarkers
  • Cell Count
  • Disease Susceptibility/immunology
  • ErbB Receptors/metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Ischemia/etiology/metabolism
  • Macrophages/immunology/metabolism
  • Macrophages
  • Alveolar/immunology/metabolism
  • Mice
  • Muscle Cells/immunology/metabolism
  • Myocardial Infarction/etiology/metabolism
  • Organ Specificity/genetics/immunology
  • Pneumonia/etiology/metabolism/pathology
Affiliation Not a UNIGE publication
Citation (ISO format)
HOYER, Friedrich Felix et al. Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenge. In: Immunity, 2019, vol. 51, n° 5, p. 899–914.e7. doi: 10.1016/j.immuni.2019.10.010
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1074-7613
197views
56downloads

Technical informations

Creation07/08/2021 5:12:00 PM
First validation07/08/2021 5:12:00 PM
Update time03/16/2023 1:05:53 AM
Status update03/16/2023 1:05:51 AM
Last indexation01/17/2024 1:58:25 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack