Scientific Article - Review
previous document  unige:154000  next document
add to browser collection
Title

New technology on the horizon: Fast analytical screening technique FNA (FAST-FNA) enables rapid, multiplex biomarker analysis in head and neck cancers

Authors
Pai, Sara I
Faquin, William C
Sadow, Peter M
Weissleder, Ralph
Published in Cancer cytopathology. 2020, vol. 128, no. 11, p. 782-791
Abstract PD-L1 profiling was recently approved by the US Food and Drug Administration as a companion diagnostic for anti-PD1 treatment in patients with head and neck cancer, ushering in a new era for precision medicine. However, the routine development and implementation of such testing is still limited by current clinical workflows and the lack of better and more comprehensive alternatives. In this review, the authors discuss the real-world challenges of clinically based biomarker testing and highlight the advantages of developing fine-needle aspiration (FNA)-based biomarker testing that would enable frequent and serial tumor sampling. A conceptual and technological innovation is introduced, fast analytical screening technique (FAST)-FNA (FAST chemistry-enabled FNA), which is being developed to inform immunotherapy treatment options in patients with head and neck cancer and to assist with the development of the next generation of predictive biomarkers.
Keywords BiomarkersTumor/analysis/metabolismBiopsyFine-NeedleEarly Detection of Cancer/instrumentation/methodsHead and Neck Neoplasms/metabolism/pathology/surgeryHumans
Identifiers
PMID: 32841527
Full text
Research group Comprendre et manipuler le système immunitaire pour lutter contre le cancer (1024)
Citation
(ISO format)
PAI, Sara I et al. New technology on the horizon: Fast analytical screening technique FNA (FAST-FNA) enables rapid, multiplex biomarker analysis in head and neck cancers. In: Cancer Cytopathology, 2020, vol. 128, n° 11, p. 782-791. doi: 10.1002/cncy.22305 https://archive-ouverte.unige.ch/unige:154000

50 hits

1 download

Update

Deposited on : 2021-08-20

Export document
Format :
Citation style :