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Scientific article
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Tumor-promoting Ly-6G+ SiglecFhigh cells are mature and long-lived neutrophils

Published inCell Reports, vol. 32, no. 12, 108164
Publication date2020
Abstract

Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of these cells' fundamental features remain unexplored. Here, we show that tumor-infiltrating CD11b+ Ly-6G+ SiglecFhigh cells are bona fide mature neutrophils and therefore differ from other myeloid cells, including SiglecFhigh eosinophils, SiglecFhigh macrophages, and CD11b+ Ly-6G+ myeloid-derived suppressor cells. We further show that SiglecFhigh neutrophils gradually accumulate in growing tumors, where they can live for several days; this lifespan is in marked contrast to that of their SiglecFlow counterparts and neutrophils in general, which live for several hours only. Together, these findings reveal distinct attributes for tumor-promoting SiglecFhigh neutrophils and help explain their deleterious accumulation in the tumor bed.

Keywords
  • Adenocarcinoma of Lung/metabolism/pathology
  • Animals
  • Antigens
  • Ly/metabolism
  • Cell Line
  • Tumor
  • Cell Proliferation
  • Lung/pathology
  • Lung Neoplasms/metabolism/pathology
  • Male
  • Mice
  • Inbred C57BL
  • Neutrophils/pathology
  • Sialic Acid Binding Immunoglobulin-like Lectins/metabolism
Citation (ISO format)
PFIRSCHKE, Christina et al. Tumor-promoting Ly-6G+ SiglecFhigh cells are mature and long-lived neutrophils. In: Cell Reports, 2020, vol. 32, n° 12, p. 108164. doi: 10.1016/j.celrep.2020.108164
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ISSN of the journal2211-1247
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