Scientific article
Open access

Silver Diamine Fluoride (SDF) in the management of root caries in elders: a systematic review and meta-analysis

Published inSwiss Dental Journal, vol. 131, no. 5, p. 417-424
Publication date2021

This systematic review was undertaken to address the PICO question: Is silver diamine fluoride (SDF) effective in preventing and arresting root caries lesions in (RCLs) elders? Systematic literature searches were conducted of electronic databases [PubMed, Embase, and CENTRAL (Cochrane Controlled Register of Trials)] and hand searches were performed to identify studies reporting on the use of SDF in elders to prevent and arrest root caries. Prospective clinical studies were included. Two independent investigators performed the literature search and data extraction. A total of 277 studies were identified; of those 3 randomized controlled clinical trials were included for data extraction and analysis. A meta-analysis, using a fixed-effects model, was performed on the mean active RCLs present after SDF intervention compared to controls at 24 months (3 studies), and 30-36 months (2 studies) post-intervention. The fixed-effects model revealed a significant decrease in the mean new active RCLs post intervention with SDF compared to controls at both 24 months (95%CI: 0.265 - 0.638; I2=0.0%; Overall: Z=4.749, p<0.001), and at 30-36 months (95%CI: 0.329 - 0.812; I2=0.0%; Overall: Z=4.629, p<0.001). A funnel plot ruled out any publication bias and the risk of bias was judged to be low. This systematic review and meta-analysis provides evidence that the application of silver diamine fluoride prevents and arrests root caries in elders.

  • Aged
  • Cariostatic Agents
  • Dental Caries/drug therapy/prevention & control
  • Fluorides
  • Topical
  • Humans
  • Prospective Studies
  • Quaternary Ammonium Compounds
  • Root Caries/drug therapy/prevention & control
  • Silver Compounds
Citation (ISO format)
GRANDJEAN, Marie-Laure et al. Silver Diamine Fluoride (SDF) in the management of root caries in elders: a systematic review and meta-analysis. In: Swiss Dental Journal, 2021, vol. 131, n° 5, p. 417–424.
Main files (1)
Article (Published version)
ISSN of the journal2296-6498

Technical informations

Creation07/16/2021 9:08:00 AM
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