Silver Diamine Fluoride (SDF) in the management of root caries in elders: a systematic review and meta-analysis

Article Article scientifique Méta-analyse Silver Diamine Fluoride (SDF) in the management of root caries in elders: a systematic review and meta-analysis eng 2021 author Grandjean Marie-Laure 864556 author Maccarone-Ruetsche Nadia 903480 author McKenna Gerald author Muller Frauke 0000-0003-3981-0134 135177 author Srinivasan Murali 742760 417-424 10.61872/sdj-2021-05-02 33515230 2296-6498 This systematic review was undertaken to address the PICO question: Is silver diamine fluoride (SDF) effective in preventing and arresting root caries lesions in (RCLs) elders? Systematic literature searches were conducted of electronic databases [PubMed, Embase, and CENTRAL (Cochrane Controlled Register of Trials)] and hand searches were performed to identify studies reporting on the use of SDF in elders to prevent and arrest root caries. Prospective clinical studies were included. Two independent investigators performed the literature search and data extraction. A total of 277 studies were identified; of those 3 randomized controlled clinical trials were included for data extraction and analysis. A meta-analysis, using a fixed-effects model, was performed on the mean active RCLs present after SDF intervention compared to controls at 24 months (3 studies), and 30-36 months (2 studies) post-intervention. The fixed-effects model revealed a significant decrease in the mean new active RCLs post intervention with SDF compared to controls at both 24 months (95%CI: 0.265 - 0.638; I2=0.0%; Overall: Z=4.749, p<0.001), and at 30-36 months (95%CI: 0.329 - 0.812; I2=0.0%; Overall: Z=4.629, p<0.001). A funnel plot ruled out any publication bias and the risk of bias was judged to be low. This systematic review and meta-analysis provides evidence that the application of silver diamine fluoride prevents and arrests root caries in elders. Aged Cariostatic Agents Dental Caries/drug therapy/prevention & control Fluorides Topical Humans Prospective Studies Quaternary Ammonium Compounds Root Caries/drug therapy/prevention & control Silver Compounds Dewey 617.6 212 Division de gérodontologie et prothèse adjointe 24Q3 false 467 Groupe de recherche Frauke Müller 797 Swiss Dental Journal 131 5 24442866-2005-4e45-82fe-6eaf2c228402 Article (Published version) Public Grand-Jean_Marie-Laure_SWISS_Dent_J_2021-05-02.pdf 419698 application/pdf openAccess Faculté de médecine / Section de médecine dentaire / Département de réhabilitation oro-faciale / Division de gérodontologie et prothèse adjointe

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Silver Diamine Fluoride (SDF) in the management of root caries in elders: a systematic review and meta-analysis	Swiss Dental Journal			2021	576	680

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