Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
Published inNature Communications, vol. 12, no. 1, 4458
Publication date2021
Abstract
Keywords
- Animals
- Blood Glucose / metabolism
- Body Weight
- Cell Lineage / genetics
- Female
- Gene Knock-In Techniques
- Humans
- Insulin / biosynthesis
- Insulin-Secreting Cells / classification
- Insulin-Secreting Cells / cytology
- Insulin-Secreting Cells / metabolism
- Male
- Mice
- Mice, Transgenic
- Pancreas / cytology
- Pancreas / embryology
- Pancreas / growth & development
- Pancreatic Polypeptide / deficiency
- Pancreatic Polypeptide / genetics
- Pancreatic Polypeptide / metabolism
- Pancreatic Polypeptide-Secreting Cells / classification
- Pancreatic Polypeptide-Secreting Cells / cytology
- Pancreatic Polypeptide-Secreting Cells / metabolism
- Pregnancy
- Protein Precursors / metabolism
- RNA-Seq
Research groups
Funding
- Autre - This work was funded with grants from Swiss National Science Foundation, European Research Council, and Fondation Aclon to P.L.H
Citation (ISO format)
PEREZ FRANCES, Marta et al. Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. In: Nature Communications, 2021, vol. 12, n° 1, p. 4458. doi: 10.1038/s41467-021-24788-0
Main files (1)
Article (Published version)
Secondary files (2)
Identifiers
- PID : unige:153672
- DOI : 10.1038/s41467-021-24788-0
- PMID : 34294685
Commercial URLhttp://www.nature.com/articles/s41467-021-24788-0
ISSN of the journal2041-1723