Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial

Chatzis, Olga; Blanchard Rohner, Géraldine; Mondoulet, L; Pelletier, B; De Gea-Hominal, Audrey; Roux, M; Csaki Huttner, Angela; Hervé, P L; Rohr, M; Matthey, Alain; Gutknecht, G; Lemaitre, Barbara; Hayem, C; Pham, H T; Wijagkanalan, W; Lambert, Paul Henri; Benhamou, P H; Siegrist, Claire-Anne

doi:10.1016/j.cmi.2020.08.033

Scientific article

English

Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial

ContributorsChatzis, Olga; Blanchard Rohner, Géraldine; Mondoulet, L; Pelletier, B; De Gea-Hominal, Audrey; Roux, M; Csaki Huttner, Angela; Hervé, P L; Rohr, M; Matthey, Alain; Gutknecht, G; Lemaitre, Barbara; Hayem, C; Pham, H T; Wijagkanalan, W; Lambert, Paul Henri; Benhamou, P H; Siegrist, Claire-Anne

Published inClinical Microbiology and Infection, vol. 32, no. 7, p. 768-776

Publication date2020

Abstract

Protection induced by acellular vaccines can be short, requiring novel immunization strategies. Objectives of this study were to evaluate safety and capacity of a recombinant pertussis toxin (PTgen) -coated Viaskin® epicutaneous patch to recall memory responses in healthy adults.

Keywords

Antibodies, Bacterial/blood
B-Lymphocytes/chemistry/immunology
Female
Humans
Immunity, Maternally-Acquired
Immunologic Memory
Infant
Meningococcal Vaccines/administration & dosage/immunology
Neisseria meningitidis/immunology
Placenta/metabolism
Pregnancy
Seroepidemiologic Studies
United Kingdom
Vaccination/methods

Affiliation entities

Research groups

Centre de vaccinologie et d'immunologie néonatale (177)

Citation (ISO format)

CHATZIS, Olga et al. Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial. In: Clinical Microbiology and Infection, 2020, vol. 32, n° 7, p. 768–776. doi: 10.1016/j.cmi.2020.08.033

Article (Published version)

CC BY-NC-ND

Identifiers

PID : unige:152336
DOI : 10.1016/j.cmi.2020.08.033
PMID : 32896653

Journal ISSN1198-743X

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Creation02/02/2021 14:42:00

First validation02/02/2021 14:42:00

Update16/03/2023 00:44:35

Status update16/03/2023 00:44:34

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Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial

Protection induced by acellular vaccines can be short, requiring novel immunization strategies. Objectives of this study were to evaluate safety and capacity of a recombinant pertussis toxin (PTgen) -coated Viaskin® epicutaneous patch to recall memory responses in healthy adults.

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