Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial

Article Article scientifique Article Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial eng 2020 author Chatzis Olga 829704 author Blanchard Rohner Géraldine 518713 author Mondoulet L author Pelletier B author De Gea-Hominal Audrey 716308 author Roux M author Csaki Huttner Angela 788122 author Hervé P L author Rohr M author Matthey Alain 558446 author Gutknecht G author Lemaitre Barbara 649671 author Hayem C author Pham H T author Wijagkanalan W author Lambert Paul Henri 25121 author Benhamou P H author Siegrist Claire-Anne 26816 768-776 10.1016/j.cmi.2020.08.033 32896653 1198-743X Protection induced by acellular vaccines can be short, requiring novel immunization strategies. Objectives of this study were to evaluate safety and capacity of a recombinant pertussis toxin (PTgen) -coated Viaskin® epicutaneous patch to recall memory responses in healthy adults. Antibodies, Bacterial/blood B-Lymphocytes/chemistry/immunology Female Humans Immunity, Maternally-Acquired Immunologic Memory Infant Meningococcal Vaccines/administration & dosage/immunology Neisseria meningitidis/immunology Placenta/metabolism Pregnancy Seroepidemiologic Studies United Kingdom Vaccination/methods Dewey 616 Dewey 618 217 Centre de recherche clinique 201 56 Département de médecine 221 58 Département de pédiatrie, gynécologie et obstétrique 223 false 143 Centre de vaccinologie et d'immunologie néonatale 177 Clinical Microbiology and Infection 32 7 8a9c17a7-13cf-4163-97b8-f3a80e26849f Article (Published version) Public 1-s2.0-S1198743X20305164-main.pdf 1347214 application/pdf CC BY-NC-ND openAccess Faculté de médecine / Centre de recherche clinique Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial	Clinical Microbiology and Infection			2020	337	259

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De Gea-Hominal, Audrey