Background: The COVID-19 pandemic has considerably altered the regular medical education curriculum while increasingthe need for health care professionals. Senior medical students are being incrementally deployed to the front line to address theshortage of certified physicians. These students, some of whom will be fast-tracked as physicians, may lack knowledge regardingthe initial management of time-critical emergencies such as stroke. Objective: Our aim was to determine whether an e-learning module could improve asynchronous distance knowledge acquisitionof the National Institutes of Health Stroke Scale (NIHSS) in senior medical students compared to the traditional didactic video