UNIGE document Scientific Article
previous document  unige:151348  next document
add to browser collection
Title

Metamorphosis of supercritical fluid chromatography: A viable tool for the analysis of polar compounds?

Authors
Published in TrAC. Trends in analytical chemistry. 2021, vol. 141, 116304
Abstract Recent developments in supercritical fluid chromatography (SFC) have highlighted the applicability of this technique for the analysis of highly polar compounds. The combination of polar stationary phases and CO2-based mobile phases with an increasing presence of liquid co-solvent (up to 100%) has enabled to further expand the application field of SFC towards a variety of samples such as polar endogenous metabolites, plant extracts, water-soluble vitamins, pesticides, sugars, peptides and so on. In this evolution, a key role was played by the addition of up to 5e10% of water in the liquid co-solvent. Moreover, the presence of water enabled higher concentrations of additives, up to 75e100 mM in some cases. These improved conditions were fundamental in expanding the applicability range of SFC. Overall, SFC has demonstrated its evolution into a mature technique capable of offering a true alternative to liquid chromatography for the analysis of polar compounds.
Keywords Ultra-high performance supercritical fluidChromatographyMass spectrometryWater-rich organic modifierPolar analytesUnified chromatographyEnhanced fluidity chromatography
Identifiers
Full text
Structures
Research group Sciences analytiques
Citation
(ISO format)
LOSACCO, Gioacchino Luca, VEUTHEY, Jean-Luc, GUILLARME, Davy. Metamorphosis of supercritical fluid chromatography: A viable tool for the analysis of polar compounds?. In: TrAC Trends in Analytical Chemistry, 2021, vol. 141, p. 116304. doi: 10.1016/j.trac.2021.116304 https://archive-ouverte.unige.ch/unige:151348

135 hits

47 downloads

Update

Deposited on : 2021-04-29

Export document
Format :
Citation style :