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Scientific article
Open access
English

Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes

Published inEuropean Journal of Immunology, vol. 34, no. 12, p. 3456-3464
Publication date2004
Abstract

A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ.

Keywords
  • Antigens
  • CD/immunology
  • CD8-Positive T-Lymphocytes/immunology/metabolism
  • Humans
  • Immunologic Memory/immunology
  • Interferon-gamma/metabolism
  • Lectins
  • C-Type/immunology
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D
  • Receptors
  • Antigen
  • T-Cell/immunology
  • Receptors
  • Immunologic/immunology
  • Receptors
  • Natural Killer Cell
  • T-Lymphocyte Subsets/immunology
Funding
  • Swiss National Science Foundation - # 3100–65′357.01
Citation (ISO format)
ARLETTAZ, Lionel Aloïs Etienne et al. Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes. In: European Journal of Immunology, 2004, vol. 34, n° 12, p. 3456–3464. doi: 10.1002/eji.200425210
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0014-2980
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134downloads

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