Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes

Article Article scientifique Article Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes eng 2004 author Arlettaz Lionel Aloïs Etienne 97577 author Villard Jean 29595 author De Rham Casimir 533538 author Degermann-Hammel Sylvie 135324 author Chapuis Bernard 24001 author Huard Bertrand 133420 author Roosnek Eddy Emile 27236 3456-3464 10.1002/eji.200425210 15517612 0014-2980 A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ. Antigens CD/immunology CD8-Positive T-Lymphocytes/immunology/metabolism Humans Immunologic Memory/immunology Interferon-gamma/metabolism Lectins C-Type/immunology NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D Receptors Antigen T-Cell/immunology Receptors Immunologic/immunology Receptors Natural Killer Cell T-Lymphocyte Subsets/immunology Dewey 616 Swiss National Science Foundation # 3100–65′357.01 CH 56 Département de médecine 221 false 298 Transplantation immunologie et osteoimmunologie 561 European Journal of Immunology 34 12 2efcde0f-9ace-497f-97c1-011eaf80d36c Article (Published version) Public eji.200425210.pdf 915786 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes	European Journal of Immunology			2004	263	208

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Degermann-Hammel, Sylvie