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Cell heterogeneity and paracrine interactions in human islet function: a perspective focused in β-cell regeneration strategies

Published inFrontiers in Endocrinology, vol. 11, 619150
Publication date2021
Abstract

The β-cell regeneration field has shown a strong knowledge boost in the last 10 years. Pluripotent stem cell differentiation and direct reprogramming from other adult cell types are becoming more tangible long-term diabetes therapies. Newly generated β-like-cells consistently show hallmarks of native β-cells and can restore normoglycemia in diabetic mice in virtually all recent studies. Nonetheless, these cells still show important compromises in insulin secretion, cell metabolism, electrical activity, and overall survival, perhaps due to a lack of signal integration from other islet cells. Mounting data suggest that diabetes is not only a β-cell disease, as the other islet cell types also contribute to its physiopathology. Here, we present an update on the most recent studies of islet cell heterogeneity and paracrine interactions in the context of restoring an integrated islet function to improve β-cell replacement therapies.

Keywords
  • Beta-Cell Regeneration
  • Cell Heterogeneity
  • Glucose Homeostasis
  • Human Islet
  • Paracrine Signaling
Funding
  • Swiss National Science Foundation - 310030_L92496
  • European Commission - MEtabolic Cell Reprogramming for the Recovery of Lost INsulin-Producing Cells [884449]
Citation (ISO format)
BRU TARI, Eva Maria, OROPEZA, Daniel, HERRERA, Pedro Luis. Cell heterogeneity and paracrine interactions in human islet function: a perspective focused in β-cell regeneration strategies. In: Frontiers in Endocrinology, 2021, vol. 11, p. 619150. doi: 10.3389/fendo.2020.619150
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Article (Published version)
Identifiers
ISSN of the journal1664-2392
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Creation02/05/2021 8:50:00 AM
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