Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease

Lamacchia, Céline; Calderin Sollet, Zuleika; Courvoisier, Delphine; Mongin, Denis; Palmer-Lourenco, Gaby; Studer, Oliva; Gabay, Cem; Villard, Jean; Buhler, Stéphane; Finckh, Axel

doi:10.1093/rheumatology/keaa790

Scientific article

English

Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease

ContributorsLamacchia, Céline; Calderin Sollet, Zuleika; Courvoisier, Delphine; Mongin, Denis

; Palmer-Lourenco, Gaby

; Studer, Oliva; Gabay, Cem; Villard, Jean; Buhler, Stéphane

; Finckh, Axel

Published inRheumatology, e14218

Publication date2020

Abstract

To quantitatively profile the T-cell repertoire in the peripheral blood of individuals genetically at risk for RA, namely first-degree relatives of RA patients (RA-FDR) at different phases of disease development.

Keywords

T-cell receptor
Pre-clinical phases
Rheumatoid arthritis

Affiliation

Research group

Funding

Swiss National Science Foundation - 3200B0_120639
Swiss National Science Foundation - New insights in the immunogenetics of haematopoietic stem cell transplantation [310030_173237]

Citation (ISO format)

LAMACCHIA, Céline et al. Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease. In: Rheumatology, 2020, p. e14218. doi: 10.1093/rheumatology/keaa790

Article (Published version)

Identifiers

PID : unige:149205
DOI : 10.1093/rheumatology/keaa790
PMID : 33291148

ISSN of the journal1462-0324

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Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease

To quantitatively profile the T-cell repertoire in the peripheral blood of individuals genetically at risk for RA, namely first-degree relatives of RA patients (RA-FDR) at different phases of disease development.

Technical informations