Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease

To quantitatively profile the T-cell repertoire in the peripheral blood of individuals genetically at risk for RA, namely first-degree relatives of RA patients (RA-FDR) at different phases of disease development.

Keywords

T-cell receptor
Pre-clinical phases
Rheumatoid arthritis

UNIGE affiliation entities

UNIGE research groups

Funding

Swiss National Science Foundation - 3200B0_120639
Swiss National Science Foundation - New insights in the immunogenetics of haematopoietic stem cell transplantation [173237]

Citation (ISO format)

LAMACCHIA, Céline et al. Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease. In: Rheumatology, 2020, p. e14218. doi: 10.1093/rheumatology/keaa790

Article (Published version)

Supplemental data

Identifiers

PID : unige:149205
DOI : 10.1093/rheumatology/keaa790
PMID : 33291148

Journal ISSN

1462-0324

344views

9downloads

Creation

04/02/2021 09:40:00

First validation

04/02/2021 09:40:00

Update

03/02/2025 12:52:24

Status update

03/02/2025 12:52:24

Last indexation

03/02/2025 12:58:01

Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease

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Abstract