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Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease

ContributorsTournier, Benjamin; Tsartsalis, Stergiosorcid; Ceyzeriat, Kelly; Fraser, Ben H; Grégoire, Marie-Claude; Kovari, Eniko Veronika; Millet, Philippeorcid
Published inJournal of Alzheimer's Disease, vol. 77, no. 3, p. 1043-1056
Publication date2020
Abstract

In vivo PET/SPECT imaging of neuroinflammation is primarily based on the estimation of the 18 kDa-translocator-protein (TSPO). However, TSPO is expressed by different cell types which complicates the interpretation.

Keywords
  • Alzheimer's disease
  • Amyloid
  • FACS-RTT
  • Neuroinflammation
  • TgF344-AD
  • TSPO
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Citation (ISO format)
TOURNIER, Benjamin et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease. In: Journal of Alzheimer’s Disease, 2020, vol. 77, n° 3, p. 1043–1056. doi: 10.3233/JAD-200136
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Additional URL for this publicationhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad200136
Journal ISSN1387-2877
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Creation28/11/2020 15:03:00
First validation28/11/2020 15:03:00
Update13/10/2025 16:40:15
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