Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease

Tournier, Benjamin; Tsartsalis, Stergios; Ceyzeriat, Kelly; Fraser, Ben H; Grégoire, Marie-Claude; Kovari, Eniko Veronika; Millet, Philippe

doi:10.3233/JAD-200136

Scientific article

English

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease

ContributorsTournier, Benjamin; Tsartsalis, Stergios

; Ceyzeriat, Kelly; Fraser, Ben H; Grégoire, Marie-Claude; Kovari, Eniko Veronika; Millet, Philippe

Published inJournal of Alzheimer's Disease, vol. 77, no. 3, p. 1043-1056

Publication date2020

Abstract

In vivo PET/SPECT imaging of neuroinflammation is primarily based on the estimation of the 18 kDa-translocator-protein (TSPO). However, TSPO is expressed by different cell types which complicates the interpretation.

Keywords

Alzheimer's disease
Amyloid
FACS-RTT
Neuroinflammation
TgF344-AD
TSPO

Affiliation entities

Research groups

Neuroimagerie moléculaire en psychiatrie (983)

Funding

Swiss National Science Foundation - Molecular Imaging of Neuroinflammation in Bipolar Disorder: a Translational Validation of the TSPO Quantification Methodology [320030_184713]

Citation (ISO format)

TOURNIER, Benjamin et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease. In: Journal of Alzheimer’s Disease, 2020, vol. 77, n° 3, p. 1043–1056. doi: 10.3233/JAD-200136

Article (Published version)

CC BY-NC

Identifiers

PID : unige:146937
DOI : 10.3233/JAD-200136
PMID : 32804124

Commercial URLhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad200136

ISSN of the journal1387-2877

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Creation28/11/2020 15:03:00

First validation28/11/2020 15:03:00

Update time15/03/2023 23:47:15

Status update15/03/2023 23:47:14

Last indexation02/10/2024 09:43:18

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Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease

In vivo PET/SPECT imaging of neuroinflammation is primarily based on the estimation of the 18 kDa-translocator-protein (TSPO). However, TSPO is expressed by different cell types which complicates the interpretation.

Technical informations