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Scientific article
English

Organization and functions of sphingolipid biosynthesis in yeast

ContributorsRiezman, Howard
Published inBiochemical Society Transactions, vol. 34, no. 3, p. 367-369
Publication date2006
Abstract

Sphingolipids are important signalling molecules and thus it is very important to understand how they are generated. Sphingolipid biosynthesis shows a conserved compartmentalization in eukaryotic cells. Their synthesis begins in the endoplasmic reticulum and is completed in the Golgi apparatus. We now know quite a bit about the topology of the reactions in the pathway, but certain critical steps, such as ceramide synthesis, are still poorly understood. In the present paper, we discuss the latest views on this subject.

Keywords
  • Ceramide synthase
  • Endoplasmic reticulum
  • Inositolphosphorylceramide
  • Serine palmitoyltransferase
  • Sphingolipid biosynthesis
  • Yeast
Citation (ISO format)
RIEZMAN, Howard. Organization and functions of sphingolipid biosynthesis in yeast. In: Biochemical Society Transactions, 2006, vol. 34, n° 3, p. 367–369. doi: 10.1042/BST0340367
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ISSN of the journal0300-5127
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