UNIGE document Scientific Article
previous document  unige:145480  next document
add to browser collection
Title

Metabolomics for early detection of stress in freshwater alga Poterioochromonas malhamensis exposed to silver nanoparticles

Authors
Majumdar, Sanghamitra
Li, Weiwei
Keller, Arturo A.
Published in Scientific Reports. 2020, vol. 10, no. 20563
Abstract Silver nanoparticles (AgNPs) are one of the most used engineered nanomaterials. Despite progress in assessing their environmental implications, knowledge gaps exist concerning the metabolic perturbations induced by AgNPs on phytoplankton, essential organisms in global biogeochemical cycles and food-web dynamics. We combine targeted metabolomics, biouptake and physiological response studies to elucidate metabolic perturbations in alga Poterioochromonas malhamensis induced by AgNPs and dissolved Ag. We show time-dependent perturbation of the metabolism of amino acids, nucleotides, fatty acids, tricarboxylic acids, photosynthesis and photorespiration by both Ag-treatments. The results suggest that dissolved Ag ions released by AgNPs are the major toxicity driver; however, AgNPs internalized in food vacuoles contributed to the perturbation of amino acid metabolism, TCA cycle and oxidative stress. The metabolic perturbations corroborate the observed physiological responses. We highlight the potential of metabolomics as a tool for understanding the molecular basis for these metabolic and physiological changes, and for early detection of stress.
Keywords NanoparticlesMetabolomicsAlgaeEcotoxicology
Identifiers
Full text
Structures
Research groups Environmental Biogeochemistry and Ecotoxicology
ISE Pôle Sciences
ISE Eau
Projects FNS: IZSEZ0_180186
1901515
Citation
(ISO format)
LIU, Wei et al. Metabolomics for early detection of stress in freshwater alga Poterioochromonas malhamensis exposed to silver nanoparticles. In: Scientific Reports, 2020, vol. 10, n° 20563. doi: 10.1038/s41598-020-77521-0 https://archive-ouverte.unige.ch/unige:145480

164 hits

22 downloads

Update

Deposited on : 2020-11-30

Export document
Format :
Citation style :