CCR5 tyrosine sulfation heterogeneity generates cell surface receptor subpopulations with different ligand binding properties

Scurci, Ilaria; Akondi, Kalyana Bharati; De Magalhaes Pinheiro, Inês; Paolini-Bertrand, Marianne; Borgeat, Alexia; Cerini, Fabrice; Hartley, Oliver

doi:10.1016/j.bbagen.2020.129753

Scientific article

English

CCR5 tyrosine sulfation heterogeneity generates cell surface receptor subpopulations with different ligand binding properties

ContributorsScurci, Ilaria; Akondi, Kalyana Bharati; De Magalhaes Pinheiro, Inês; Paolini-Bertrand, Marianne; Borgeat, Alexia; Cerini, Fabrice; Hartley, Oliver

Published inBiochimica et Biophysica Acta - General Subjects, vol. 1865, no. 1, 129753

Publication date2020

Abstract

Chemokine receptor tyrosine sulfation plays a key role in the binding of chemokines. It has been suggested that receptor sulfation is heterogeneous, but no experimental evidence has been provided so far. The potent anti-HIV chemokine analog 5P12-RANTES has been proposed to owe its inhibitory activity to a capacity to bind a larger pool of cell surface CCR5 receptors than native chemokines such as CCL5, but the molecular details underlying this phenomenon have not been elucidated.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Protein and peptide engineering for medicine (835)

Funding

Citation (ISO format)

SCURCI, Ilaria et al. CCR5 tyrosine sulfation heterogeneity generates cell surface receptor subpopulations with different ligand binding properties. In: Biochimica et Biophysica Acta - General Subjects, 2020, vol. 1865, n° 1, p. 129753. doi: 10.1016/j.bbagen.2020.129753