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Deficiency in insulin-like growth factors signalling in mouse Leydig cells increase conversion of testosterone to estradiol because of feminization

ContributorsRadovic Pletikosic, Sava M; Starovlah, Isidora M; Miljkovic, Dejan; Bajic, Dragana M; Capo, Ivan; Nef, Sergeorcid; Kostic, Tatjana S; Andric, Silvana A
Published inActa Physiologica, e13563
Publication date2020
Abstract

A growing body of evidence pointed correlation between insulin-resistance, testosterone level and infertility, but there is scarce information about mechanisms. The aim of this study was to identify the possible mechanism linking the insulin-resistance with testosterone-producing-Leydig-cells functionality.

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RADOVIC PLETIKOSIC, Sava M et al. Deficiency in insulin-like growth factors signalling in mouse Leydig cells increase conversion of testosterone to estradiol because of feminization. In: Acta Physiologica, 2020, p. e13563. doi: 10.1111/apha.13563
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accessLevelRestricted
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Journal ISSN1748-1708
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Creation10/11/2020 19:22:00
First validation10/11/2020 19:22:00
Update17/01/2025 16:19:07
Status update17/01/2025 16:19:07
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