Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity
ContributorsPanousis, Nikolaos; Bertsias, George K; Ongen, Halit; Gergianaki, Irini; Tektonidou, Maria G; Trachana, Maria; Romano, Luciana; Bielser, Deborah; Howald, Cédric; Pamfil, Cristina; Fanouriakis, Antonis; Kosmara, Despoina; Repa, Argyro; Sidiropoulos, Prodromos; Dermitzakis, Emmanouil; Boumpas, Dimitrios T
Published inAnnals of the Rheumatic Diseases, vol. 78, no. 8, p. 1079-1089
Publication date2019
Abstract
Keywords
- Adult
- Case-Control Studies
- Disease Progression
- Female
- Gene Expression Profiling/methods
- Genetic Predisposition to Disease/epidemiology
- Genetic Variation
- Genome-Wide Association Study
- Genotype
- Humans
- Interferon Type I/genetics
- Lupus Erythematosus
- Systemic/genetics/immunology
- Male
- Middle Aged
- Phenotype
- RNA
- Messenger/genetics
- Reference Values
- Transcriptome/genetics
- Young Adult
Research group
Funding
- Swiss National Science Foundation - Elucidating the effects of germ-line and somatic regulatory DNA sequence variants in health and disease [31003A_170096]
- European Commission - PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) [742390]
- European Commission - A Systems medicine approach to chronic inflammatory disease [733100]
Citation (ISO format)
PANOUSIS, Nikolaos et al. Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity. In: Annals of the Rheumatic Diseases, 2019, vol. 78, n° 8, p. 1079–1089. doi: 10.1136/annrheumdis-2018-214379
Main files (1)
Article (Published version)
Identifiers
- PID : unige:144675
- DOI : 10.1136/annrheumdis-2018-214379
- PMID : 31167757
ISSN of the journal0003-4967
