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Title

Generation of insulin-secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

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Published in Transplant International. 2020
Abstract Diabetes is a major health issue of increasing prevalence. ß-cell replacement, by pancreas or islet transplantation, is the only long-term curative option for patients with insulin-dependent diabetes. Despite good functional results, pancreas transplantation remains a major surgery with potentially severe complications. Islet transplantation is a minimally invasive alternative that can widen the indications in view of its lower morbidity. However, the islet isolation procedure disrupts their vasculature and connection to the surrounding extracellular matrix, exposing them to ischemia and anoikis. Implanted islets are also the target of innate and adaptive immune attacks, thus preventing robust engraftment and prolonged full function. Generation of organoids, defined as functional 3D structures assembled with cell types from different sources, is a strategy increasingly used in regenerative medicine for tissue replacement or repair, in a variety of inflammatory or degenerative disorders. Applied to ß-cell replacement, it offers the possibility to control the size and composition of islet-like structures (pseudo-islets), and to include cells with anti-inflammatory or immunomodulatory properties. In this review, we will present approaches to generate islet cell organoids and discuss how these strategies can be applied to the generation of a bioartificial pancreas for the treatment of type 1 diabetes.
Keywords BioengineeringCell transplantationIslet transplantationOrganoidsType 1 diabetes
Identifiers
PMID: 32852858
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Structures
Research groups Création de tissus par bio-ingénieurie et régénération d'organes (1021)
La transplantation d'îlots de Langerhans (623)
Projects FNS: 310030_170090, 310030_173138
Juvenile Diabetes Research Foundation International. Grant Number: 3‐SRA‐2020‐926‐S‐B
Shota Rustaveli National Science Foundation. Grant Number: FR‐19‐19760
H2020: VANGUARD
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WASSMER, Charles-Henri et al. Generation of insulin-secreting organoids: a step toward engineering and transplanting the bioartificial pancreas. In: Transplant International, 2020. doi: 10.1111/tri.13721 https://archive-ouverte.unige.ch/unige:144616

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Deposited on : 2020-11-11

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