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Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS)

Published inClinical Microbiology and Infection, vol. 24, no. 11, p. 1214.e1-1214.e4
Publication date2018
Abstract

Echinocandins represent the first-line treatment of candidaemia. Acquired echinocandin resistance is mainly observed among Candida albicans and Candida glabrata and is associated with FKS hotspot mutations. The commercial Sensititre YeastOne™ (SYO) kit is widely used for antifungal susceptibility testing, but interpretive clinical breakpoints are not well defined. We determined echinocandins epidemiological cut-off values (ECV) for C. albicans/glabrata tested by SYO and assessed their ability to identify FKS mutants in a national survey of candidaemia.

Keywords
  • Antifungal Agents/pharmacology
  • Candida albicans/genetics
  • Candida glabrata
  • Candidiasis/microbiology
  • Drug Resistance
  • Fungal
  • Echinocandins/administration & dosage/pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Population Surveillance
  • Switzerland/epidemiology
Citation (ISO format)
KRITIKOS, A et al. Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS). In: Clinical Microbiology and Infection, 2018, vol. 24, n° 11, p. 1214.e1–1214.e4. doi: 10.1016/j.cmi.2018.05.012
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ISSN of the journal1198-743X
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