Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS)

Kritikos, A; Neofytos, Dionysios; Khanna, N; Schreiber, P W; Boggian, K; Bille, J; Schrenzel, Jacques; Mühlethaler, K; Zbinden, R; Bruderer, T; Goldenberger, D; Pfyffer, G; Conen, A; Van Delden, Christian; Zimmerli, S; Sanglard, D; Bachmann, D; Marchetti, O; Lamoth, F; Fungal Infection Network of Switzerland (FUNGINOS)

doi:10.1016/j.cmi.2018.05.012

Scientific article

English

Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS)

ContributorsKritikos, A; Neofytos, Dionysios; Khanna, N; Schreiber, P W; Boggian, K; Bille, J; Schrenzel, Jacques; Mühlethaler, K; Zbinden, R; Bruderer, T; Goldenberger, D; Pfyffer, G; Conen, A; Van Delden, Christian; Zimmerli, S; Sanglard, D; Bachmann, D; Marchetti, O; Lamoth, F; Fungal Infection Network of Switzerland (FUNGINOS)

Published inClinical Microbiology and Infection, vol. 24, no. 11, p. 1214.e1-1214.e4

Publication date2018

Abstract

Echinocandins represent the first-line treatment of candidaemia. Acquired echinocandin resistance is mainly observed among Candida albicans and Candida glabrata and is associated with FKS hotspot mutations. The commercial Sensititre YeastOne™ (SYO) kit is widely used for antifungal susceptibility testing, but interpretive clinical breakpoints are not well defined. We determined echinocandins epidemiological cut-off values (ECV) for C. albicans/glabrata tested by SYO and assessed their ability to identify FKS mutants in a national survey of candidaemia.

Keywords

Antifungal Agents/pharmacology
Candida albicans/genetics
Candida glabrata
Candidiasis/microbiology
Drug Resistance
Fungal
Echinocandins/administration & dosage/pharmacology
Humans
Microbial Sensitivity Tests
Mutation
Population Surveillance
Switzerland/epidemiology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

KRITIKOS, A et al. Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS). In: Clinical Microbiology and Infection, 2018, vol. 24, n° 11, p. 1214.e1–1214.e4. doi: 10.1016/j.cmi.2018.05.012

Article (Published version)

OA OTHER

Identifiers

PID : unige:143908
DOI : 10.1016/j.cmi.2018.05.012
PMID : 29909005

Journal ISSN1198-743X

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Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS)

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