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English

Adverse side effects and route of administration of opioids in combined spinal-epidural analgesia for labour: a meta-analysis of randomised trials

Published inInternational Journal of Obstetric Anesthesia, vol. 41, p. 83-103
Publication date2020
Abstract

Studies report an increased risk of maternal and fetal adverse side effects when combined spinal-epidural, rather than standard epidural, analgesia is provided for labour and delivery. Intrathecal opioids used with local anaesthetic in combined spinal-epidural analgesia may be a cause. It is not known whether this is due to the addition of opioid to local anaesthetic in the intrathecal space only or due to concomitant administration into the intrathecal and epidural spaces.

Keywords
  • Combined spinal-epidural analgesia
  • Epidural analgesia
  • Intrathecal or spinal analgesia
  • Labour
  • Opioid side effects
Citation (ISO format)
GRANGIER, Lorraine et al. Adverse side effects and route of administration of opioids in combined spinal-epidural analgesia for labour: a meta-analysis of randomised trials. In: International Journal of Obstetric Anesthesia, 2020, vol. 41, p. 83–103. doi: 10.1016/j.ijoa.2019.09.004
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ISSN of the journal0959-289X
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Creation09/17/2020 1:34:00 PM
First validation09/17/2020 1:34:00 PM
Update time03/15/2023 10:53:42 PM
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