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Pancreas collagen digestion during islet of Langerhans isolation

ContributorsMeier, Raphael; Meyer, Jérémyorcid; Muller, Yannick; Szot, Gregory; Bedat, Benoît; Andres, Axel; Massé, Nathalie; Lablanche, Sandrine; Puppa, Giacomo; Bosco, Domenico; Berney, Thierry
Published inTransplant International, vol. 33, no. 11, p. 1516-1528
Publication date2020
Abstract

The success of pancreas islet isolation largely depends on donor characteristics, including extracellular matrix composition of which collagen is the main element. We hypothesized that isolation yields are proportional to collagen digestion percentage, and aimed to determine a threshold that predicts isolation success.

Keywords
  • Islet isolation
  • Type 1 diabetes mellitus
  • Collagen
  • Collagenase
  • Extracellular matrix
  • Islet of Langerhans
  • Islet transplantation
  • Outcomes
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Funding
Citation (ISO format)
MEIER, Raphael et al. Pancreas collagen digestion during islet of Langerhans isolation. In: Transplant International, 2020, vol. 33, n° 11, p. 1516–1528. doi: 10.1111/tri.13725
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Identifiers
Additional URL for this publicationhttps://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13725
Journal ISSN0934-0874
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Technical informations

Creation09/08/2020 4:47:00 PM
First validation09/08/2020 4:47:00 PM
Update time01/17/2025 4:23:28 PM
Status update01/17/2025 4:23:28 PM
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