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Pancreas collagen digestion during islet of Langerhans isolation

ContributorsMeier, Raphael; Meyer, Jérémyorcid; Muller, Yannick; Szot, Gregory; Bedat, Benoît; Andres, Axel; Massé, Nathalie; Lablanche, Sandrine; Puppa, Giacomo; Bosco, Domenico; Berney, Thierry
Published inTransplant International, vol. 33, no. 11, p. 1516-1528
Publication date2020
Abstract

The success of pancreas islet isolation largely depends on donor characteristics, including extracellular matrix composition of which collagen is the main element. We hypothesized that isolation yields are proportional to collagen digestion percentage, and aimed to determine a threshold that predicts isolation success.

Keywords
  • Islet isolation
  • Type 1 diabetes mellitus
  • Collagen
  • Collagenase
  • Extracellular matrix
  • Islet of Langerhans
  • Islet transplantation
  • Outcomes
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Funding
Citation (ISO format)
MEIER, Raphael et al. Pancreas collagen digestion during islet of Langerhans isolation. In: Transplant International, 2020, vol. 33, n° 11, p. 1516–1528. doi: 10.1111/tri.13725
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Additional URL for this publicationhttps://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13725
Journal ISSN0934-0874
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Creation08/09/2020 16:47:00
First validation08/09/2020 16:47:00
Update13/10/2025 16:54:32
Status update17/01/2025 16:23:28
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