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Title

Cell therapy for type 2 diabetes: is it desirable and can we get it?

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Published in Diabetes, Obesity and Metabolism. 2008, vol. 10, no. Suppl 4, p. 205-11
Abstract The functional mass of beta-cells is decreased in type 2 diabetes. Replacing missing beta-cells or triggering their regeneration may thus allow for improved treatment of type 2 diabetes, to the extent that this is combined with therapy for improved insulin sensitivity. Although progress has been made in deriving beta-cell-like cells from stem or precursor cells in vitro, these cannot yet be obtained in sufficient quantities or well enough differentiated to envisage their therapeutic use in beta-cell replacement therapy. Likewise, our very limited understanding of beta-cell regeneration in adult man does not yet allow for development of a valid strategy for kick-starting such a process in individuals with type 2 diabetes, whether by bona fide neogenesis or self-replication of existing beta-cells. Regardless of how beta-cell mass is restored in type 2 diabetes, it will be important to prevent any renewed decrease thereafter. Current understanding suggests that islet inflammation as well as signals from (insulin-resistant/inflamed) adipose tissue and skeletal muscle contribute towards decreased beta-cell mass in type 2 diabetes. It will likely be important to protect newly formed or implanted beta-cells from these negative influences to ensure their long-term survival.
Keywords AnimalsDiabetes Mellitus, Type 2/physiopathology/therapyFemaleHistory, 18th CenturyHistory, 19th CenturyHistory, 20th CenturyHistory, 21st CenturyHumansInsulin Resistance/physiologyIslets of Langerhans/cytology/physiologyMaleStem Cell Transplantation/methods/trendsTissue Therapy/methods/trends
Stable URL https://archive-ouverte.unige.ch/unige:1431
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PMID: 18834449
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Research group Fonction de l'îlot de Langerhans (324)

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Deposited on : 2009-04-28

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