Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Ruiz Altaba, Ariel

doi:10.1016/j.ccr.2008.09.007

Scientific article

English

Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

ContributorsRuiz Altaba, Ariel

Published inCancer cell, vol. 14, no. 4, p. 281-283

Publication date2008

Abstract

Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.

Keywords

Animals
Antineoplastic Agents/pharmacology
Cell Proliferation/drug effects
Cell Survival/drug effects
Epithelial Cells/drug effects/metabolism
Hedgehog Proteins/metabolism
Humans
Neoplasms/drug therapy/metabolism/pathology
Neoplastic Stem Cells/drug effects/metabolism
Paracrine Communication/drug effects
Receptors, G-Protein-Coupled/antagonists & inhibitors/metabolism
Signal Transduction/drug effects
Stromal Cells/drug effects/metabolism
Transcription Factors/metabolism

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Research group

Stemness dans le développement et les maladies: Signalisation, reprogrammation et mécanismes des métastases (776)

Citation (ISO format)

RUIZ ALTABA, Ariel. Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? In: Cancer cell, 2008, vol. 14, n° 4, p. 281–283. doi: 10.1016/j.ccr.2008.09.007

Article (Accepted version)

Identifiers

PID : unige:1430
DOI : 10.1016/j.ccr.2008.09.007
PMID : 18835029

ISSN of the journal1535-6108

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Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

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