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Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

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Published in Cancer Cell. 2008, vol. 14, no. 4, p. 281-3
Abstract Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.
Keywords AnimalsAntineoplastic Agents/pharmacologyCell Proliferation/drug effectsCell Survival/drug effectsEpithelial Cells/drug effects/metabolismHedgehog Proteins/metabolismHumansNeoplasms/drug therapy/metabolism/pathologyNeoplastic Stem Cells/drug effects/metabolismParacrine Communication/drug effectsReceptors, G-Protein-Coupled/antagonists & inhibitors/metabolismSignal Transduction/drug effectsStromal Cells/drug effects/metabolismTranscription Factors/metabolism
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PMID: 18835029
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Research group Morphologie de l'organisme et rôle des protéines GLI (776)
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RUIZ ALTABA, Ariel. Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?. In: Cancer Cell, 2008, vol. 14, n° 4, p. 281-3. https://archive-ouverte.unige.ch/unige:1430

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Deposited on : 2009-04-28

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