en
Scientific article
English

Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes

Published inOphthalmologica, vol. 237, no. 4, p. 232-237
Publication date2017
Abstract

Purpose: To evaluate the efficacy of intravitreal dexamethasone implant for the treatment of postoperative persistent cystoid macular edema (CME) following macular pucker surgery. Methods: In this multicenter study, we retrospectively reviewed the data of 37 patients (39 eyes) who had been treated with intravitreal dexamethasone implant (Ozurdex®) for persistent CME following macular pucker surgery. Main outcome measures were change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). Results: All eyes underwent spectral domain optical coherence tomography examination within 130 days after implantation. We observed a significant decrease in mean CRT from 519.9 to 392.9 µm (p < 0.0001). By this time, mean BCVA had improved from 0.60 to 0.43 logMAR (p = 0.003). Seventeen eyes (43.6%) required at least 1 repeat injection of dexamethasone. Of these, 8 (47%) eyes received a total number of 3 or more dexamethasone injections. Conclusion: Intravitreal dexamethasone implant injection is an effective treatment option for persistent CME following macular pucker surgery. Keywords: Central retinal thickness; Dexamethasone implant; Fluocinolone acetonide implant; Intravitreal steroid implants; Long-term outcome; Macular pucker surgery; Membrane peeling; Pars plana vitrectomy; Persistent macular edema.

Keywords
  • Aged
  • Delayed-Action Preparations
  • Dexamethasone/administration & dosage
  • Drug Implants
  • Epiretinal Membrane/diagnosis/surgery
  • Female
  • Follow-Up Studies
  • Glucocorticoids/administration & dosage
  • Humans
  • Intravitreal Injections
  • Macula Lutea/pathology
  • Macular Edema/diagnosis/drug therapy/etiology
  • Male
  • Postoperative Complications
  • Retrospective Studies
  • Time Factors
  • Tomography
  • Optical Coherence
  • Treatment Outcome
  • Visual Acuity
  • Vitrectomy/adverse effects
Affiliation Not a UNIGE publication
Citation (ISO format)
HATTENBACH, Lars-Olof et al. Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes. In: Ophthalmologica, 2017, vol. 237, n° 4, p. 232–237. doi: 10.1159/000464259
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1423-0267
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