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Title

Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes

Authors
Hattenbach, Lars-Olof
Hoerauf, Hans
Callizo, Josep
Jungmann, Stephanie
Brauns, Thomas
Fulle, Gergana
Eichel, Sebastian
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Published in Ophthalmologica. 2017, vol. 237, no. 4, p. 232-237
Abstract Purpose: To evaluate the efficacy of intravitreal dexamethasone implant for the treatment of postoperative persistent cystoid macular edema (CME) following macular pucker surgery. Methods: In this multicenter study, we retrospectively reviewed the data of 37 patients (39 eyes) who had been treated with intravitreal dexamethasone implant (Ozurdex®) for persistent CME following macular pucker surgery. Main outcome measures were change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). Results: All eyes underwent spectral domain optical coherence tomography examination within 130 days after implantation. We observed a significant decrease in mean CRT from 519.9 to 392.9 µm (p < 0.0001). By this time, mean BCVA had improved from 0.60 to 0.43 logMAR (p = 0.003). Seventeen eyes (43.6%) required at least 1 repeat injection of dexamethasone. Of these, 8 (47%) eyes received a total number of 3 or more dexamethasone injections. Conclusion: Intravitreal dexamethasone implant injection is an effective treatment option for persistent CME following macular pucker surgery. Keywords: Central retinal thickness; Dexamethasone implant; Fluocinolone acetonide implant; Intravitreal steroid implants; Long-term outcome; Macular pucker surgery; Membrane peeling; Pars plana vitrectomy; Persistent macular edema.
Keywords AgedDelayed-Action PreparationsDexamethasone/administration & dosageDrug ImplantsEpiretinal Membrane/diagnosis/surgeryFemaleFollow-Up StudiesGlucocorticoids/administration & dosageHumansIntravitreal InjectionsMacula Lutea/pathologyMacular Edema/diagnosis/drug therapy/etiologyMalePostoperative ComplicationsRetrospective StudiesTime FactorsTomographyOptical CoherenceTreatment OutcomeVisual AcuityVitrectomy/adverse effects
Identifiers
PMID: 28463851
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Article (Published version) (13.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Ophtalmologie expérimentale (925)
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HATTENBACH, Lars-Olof et al. Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes. In: Ophthalmologica, 2017, vol. 237, n° 4, p. 232-237. doi: 10.1159/000464259 https://archive-ouverte.unige.ch/unige:142389

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Deposited on : 2020-10-01

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