Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes

Article Article scientifique Article Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes eng 2017 author Hattenbach Lars-Olof author Springer-Wanner Christina 927274 author Hoerauf Hans author Callizo Josep author Jungmann Stephanie author Brauns Thomas author Fulle Gergana author Eichel Sebastian author Koss Michael Janusz author Kuhli-Hattenbach Claudia 232-237 10.1159/000464259 28463851 1423-0267 Purpose: To evaluate the efficacy of intravitreal dexamethasone implant for the treatment of postoperative persistent cystoid macular edema (CME) following macular pucker surgery. Methods: In this multicenter study, we retrospectively reviewed the data of 37 patients (39 eyes) who had been treated with intravitreal dexamethasone implant (Ozurdex®) for persistent CME following macular pucker surgery. Main outcome measures were change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). Results: All eyes underwent spectral domain optical coherence tomography examination within 130 days after implantation. We observed a significant decrease in mean CRT from 519.9 to 392.9 µm (p < 0.0001). By this time, mean BCVA had improved from 0.60 to 0.43 logMAR (p = 0.003). Seventeen eyes (43.6%) required at least 1 repeat injection of dexamethasone. Of these, 8 (47%) eyes received a total number of 3 or more dexamethasone injections. Conclusion: Intravitreal dexamethasone implant injection is an effective treatment option for persistent CME following macular pucker surgery. Keywords: Central retinal thickness; Dexamethasone implant; Fluocinolone acetonide implant; Intravitreal steroid implants; Long-term outcome; Macular pucker surgery; Membrane peeling; Pars plana vitrectomy; Persistent macular edema. Aged Delayed-Action Preparations Dexamethasone/administration & dosage Drug Implants Epiretinal Membrane/diagnosis/surgery Female Follow-Up Studies Glucocorticoids/administration & dosage Humans Intravitreal Injections Macula Lutea/pathology Macular Edema/diagnosis/drug therapy/etiology Male Postoperative Complications Retrospective Studies Time Factors Tomography Optical Coherence Treatment Outcome Visual Acuity Vitrectomy/adverse effects true 582 Ophtalmologie expérimentale 925 Ophthalmologica 237 4 0719dc71-1d5d-477a-b31f-13c6d6dd2210 Article (Published version) Restricted Springer_Wanner_2017.pdf 14507264 application/pdf restrictedAccess

Title	Published in	Year	Views	Downloads

Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes	Ophthalmologica	2017	276	0
Okuläre Sarkoidose	Zeitschrift für Rheumatologie	2017	245	0

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