Scientific article

Understanding the diversity of membrane lipid composition

Published inNature Reviews Molecular Cell Biology, vol. 19, no. 5, p. 281-296
Publication date2018

Cellular membranes are formed from a chemically diverse set of lipids present in various amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from the scale of a membrane leaflet to that of a whole organism, highlighting its importance and suggesting that membrane lipids fulfil many functions. Indeed, alterations of membrane lipid homeostasis are linked to various diseases. While many of their functions remain unknown, interdisciplinary approaches have begun to reveal novel functions of lipids and their interactions. We are beginning to understand why even small changes in lipid structures and in composition can have profound effects on crucial biological functions.

Citation (ISO format)
HARAYAMA, Takeshi, RIEZMAN, Howard. Understanding the diversity of membrane lipid composition. In: Nature Reviews Molecular Cell Biology, 2018, vol. 19, n° 5, p. 281–296. doi: 10.1038/nrm.2017.138
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Article (Published version)
ISSN of the journal1471-0072

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