Scientific article

On the road to unraveling the molecular functions of ether lipids

Published inFEBS Letters, vol. 593, no. 17, p. 2378-2389
Publication date2019

Ether lipids are glycerolipids further classified into alkyl‐ether and alkenyl‐ether (also termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their synthesis. However, alkyl‐ether and alkenyl‐ether lipids differ in their structure and physico‐chemical properties (featuring different head groups) and, thus, probably in their functions. Ether lipids have intermittent distribution across the evolutionary tree and defects in their synthesis have been shown to perturb cellular homeostasis and lead to disease in humans. Here, we review their structure, their interactions with other lipids, and their potential roles in cellular functions, such as membrane homeostasis and membrane trafficking. Moreover, we discuss still unclear aspects of these lipids such as their subcellular distribution, and the need to unravel their molecular functions as well as how novel tools to study lipid biology will help clarify these aspects.

  • Ether lipids
  • Lipids
  • Membrane trafficking
  • Plasmalogens
Citation (ISO format)
JIMENEZ ROJO, Noemi, RIEZMAN, Howard. On the road to unraveling the molecular functions of ether lipids. In: FEBS Letters, 2019, vol. 593, n° 17, p. 2378–2389. doi: 10.1002/1873-3468.13465
Main files (1)
Article (Published version)
ISSN of the journal0014-5793

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