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Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

Cohen, Patrick
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Published in PLOS ONE. 2020, vol. 15, no. 9, e0238089
Abstract A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a current pandemic (COVID-19) with devastating consequences in public health and economic stability. Using a peptide array to map the antibody response of plasma from healing patients (12) and heathy patients (6), we identified three immunodominant linear epitopes, two of which correspond to key proteolytic sites on the spike protein (S1/S2 and S2’) known to be critical for cellular entry. We show biochemical evidence that plasma positive for the epitope adjacent to the S1/S2 cleavage site inhibits furin-mediated proteolysis of spike.
PMID: 32903266
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Research groups Groupe Winssinger
Chimie et protéomique clinique (270)
Groupe Laurent Kaiser (virologie clinique) (668)
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FARRERA SOLER, Lluc et al. Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma. In: PLOS ONE, 2020, vol. 15, n° 9, p. e0238089. doi: 10.1371/journal.pone.0238089 https://archive-ouverte.unige.ch/unige:141686

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Deposited on : 2020-09-22

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