SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Chae, Heeyoung; Augustin, Robert; Gatineau, Eva; Mayoux, Eric; Bensellam, Mohammed; Antoine, Nancy; Khattab, Firas; Lai, Bao-Khanh; Brusa, Davide; Stierstorfer, Birgit; Klein, Holger; Singh, Bilal; Ruiz, Lucie; Pieper, Michael; Mark, Michael; Herrera, Pedro Luis; Gribble, Fiona M.; Reimann, Frank; Wojtusciszyn, Anne; Broca, Christophe; Rita, Nano; Piemonti, Lorenzo; Gilon, Patrick

doi:10.1016/j.molmet.2020.101071

Article scientifique

Accès libre

Anglais

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Publié dansMolecular Metabolism, 101071

Date de publication2020

Résumé

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. No direct effect of SGLT2i on α- and β-cells

Mots-clés

No direct effect of SGLT2i on α- and β-cells
Gliflozins
SGLT2 inhibitor
Glucagon
Insulin
Diabetes

Structure d'affiliation

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Groupe de recherche

Types cellulaires pancréatiques pendant l'ontogénèse (522)

Citation (format ISO)

CHAE, Heeyoung et al. SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. In: Molecular Metabolism, 2020, p. 101071. doi: 10.1016/j.molmet.2020.101071