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Title

Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

Authors
van Beijnum, Judy R
Huijbers, Elisabeth J M
Gasull, Paula C
Mans, Laurie
Bex, Axel
Griffioen, Arjan W
Published in British Journal of Cancer. 2019, vol. 120, no. 2, p. 218-228
Abstract In a genomic screen for determinants of the tumour vasculature, we identified insulin receptor (INSR) to mark the tumour endothelium. As a functional role for insulin/INSR in cancer has been suggested and markers of the tumour endothelium may be attractive therapeutic targets, we investigated the role of INSR in angiogenesis.
Keywords AnimalsAntigens, CD/geneticsCell Proliferation/geneticsChick EmbryoChorioallantoic Membrane/metabolism/pathologyDisease Models, AnimalEndothelium/metabolism/pathologyFemaleGene Knockdown TechniquesGenome, Human/geneticsHuman Umbilical Vein Endothelial CellsHumansInsulin/genetics/metabolismKidney Neoplasms/genetics/pathologyMaleMiceNeovascularization, Pathologic/genetics/pathologyProtein Isoforms/geneticsRNA, Small Interfering/geneticsReceptor, Insulin/geneticsTumor Cells, Cultured
Identifiers
PMID: 30559346
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Article (Published version) (3 MB) - public document Free access
Structures
Research group Pharmacologie moléculaire
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(ISO format)
NOWAK-SLIWINSKA, Patrycja et al. Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment. In: British Journal of Cancer, 2019, vol. 120, n° 2, p. 218-228. doi: 10.1038/s41416-018-0347-8 https://archive-ouverte.unige.ch/unige:140706

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Deposited on : 2020-09-02

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