UNIGE document Scientific Article
previous document  unige:139081  next document
add to browser collection

Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary

Chassot, Anne-Amandine
Le Rolle, Morgane
Jolivet, Geneviève
Guigonis, Jean-Marie
Da Silva, Fabio
Pailhoux, Eric
show hidden authors show all authors [1 - 11]
Published in Science Advances. 2020, vol. 6, no. 21, eaaz1261
Abstract In mammals, the timing of meiosis entry is regulated by signals from the gonadal environment. All-trans retinoic acid (ATRA) signaling is considered the key pathway that promotes Stra8 (stimulated by retinoic acid 8) expression and, in turn, meiosis entry. This model, however, is debated because it is based on analyzing the effects of exogenous ATRA on ex vivo gonadal cultures, which not accurately reflects the role of endogenous ATRA. Aldh1a1 and Aldh1a2, two retinaldehyde dehydrogenases synthesizing ATRA, are expressed in the mouse ovaries when meiosis initiates. Contrary to the present view, here, we demonstrate that ATRA-responsive cells are scarce in the ovary. Using three distinct gene deletion models for Aldh1a1;Aldh1a2;Aldh1a3, we show that Stra8 expression is independent of ATRA production by ALDH1A proteins and that germ cells progress through meiosis. Together, these data demonstrate that ATRA signaling is dispensable for instructing meiosis initiation in female germ cells.
PMID: 32494737
Full text
Article (Published version) (5.1 MB) - public document Free access
Research group Mécanismes moléculaires et génétiques du développement sexuel (778)
(ISO format)
CHASSOT, Anne-Amandine et al. Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. In: Science Advances, 2020, vol. 6, n° 21, p. eaaz1261. doi: 10.1126/sciadv.aaz1261 https://archive-ouverte.unige.ch/unige:139081

116 hits



Deposited on : 2020-08-06

Export document
Format :
Citation style :