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Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors

Vernet, Nadège
Condrea, Diana
Féret, Betty
Klopfenstein, Muriel
Magnant, William
Alunni, Violaine
Telentin, Marius
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Published in Science Advances. 2020, vol. 6, no. 21, eaaz1139
Abstract Gametes are generated through a specialized cell differentiation process, meiosis, which, in ovaries of most mammals, is initiated during fetal life. All-trans retinoic acid (ATRA) is considered as the molecular signal triggering meiosis initiation. In the present study, we analyzed female fetuses ubiquitously lacking all ATRA nuclear receptors (RAR), obtained through a tamoxifen-inducible cre recombinase-mediated gene targeting approach. Unexpectedly, mutant oocytes robustly expressed meiotic genes, including the meiotic gatekeeper STRA8. In addition, ovaries from mutant fetuses grafted into adult recipient females yielded offspring bearing null alleles for all Rar genes. Thus, our results show that RAR are fully dispensable for meiotic initiation, as well as for the production of functional oocytes. Assuming that the effects of ATRA all rely on RAR, our study goes against the current model according to which meiosis is triggered by endogenous ATRA in the developing ovary. It therefore revives the search for the meiosis-inducing substance.
PMID: 32494735
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Research group Mécanismes moléculaires et génétiques du développement sexuel (778)
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VERNET, Nadège et al. Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. In: Science Advances, 2020, vol. 6, n° 21, p. eaaz1139. doi: 10.1126/sciadv.aaz1139 https://archive-ouverte.unige.ch/unige:139080

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Deposited on : 2020-08-06

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