Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate

Castex, Françoise; Leroy, Jeremy; Broca, Christophe; Mezghenna, Karima; Duranton, Flore; Lavallard, Vanessa; Lebreton, Fanny; Gross, René; Wojtusciszyn, Anne; Lajoix, Anne-Dominique

doi:10.1111/1753-0407.13026

Scientific article

English

Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate

ContributorsCastex, Françoise; Leroy, Jeremy; Broca, Christophe; Mezghenna, Karima; Duranton, Flore; Lavallard, Vanessa; Lebreton, Fanny; Gross, René; Wojtusciszyn, Anne; Lajoix, Anne-Dominique

Published inJournal of Diabetes, vol. 12, no. 7, p. 532-541

Publication date2020

Abstract

Due to the shortage of multi-organ donors, human pancreatic islet transplantation has now been extended to islets originating from obese subjects. In this study, our aim is to compare the respective sensitivity of human islets from lean vs obese donors to chronic high glucose or high palmitate.

Keywords

Human islets
Insulin secretion
Islet transplantation
Nitric oxide synthase
Obesity

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

CASTEX, Françoise et al. Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate. In: Journal of Diabetes, 2020, vol. 12, n° 7, p. 532–541. doi: 10.1111/1753-0407.13026

Article (Published version)

Identifiers

PID : unige:138412
DOI : 10.1111/1753-0407.13026
PMID : 32090456

Journal ISSN1753-0393

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Creation08/07/2020 13:26:00

First validation08/07/2020 13:26:00

Update15/03/2023 22:17:12

Status update15/03/2023 22:17:11

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Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate

Due to the shortage of multi-organ donors, human pancreatic islet transplantation has now been extended to islets originating from obese subjects. In this study, our aim is to compare the respective sensitivity of human islets from lean vs obese donors to chronic high glucose or high palmitate.

Technical informations