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Title

European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice

Authors
Buhre, Wolfgang
Disma, Nicola
Hendrickx, Jan
DeHert, Stefan
Hollmann, Markus W
Huhn, Ragnar
Jakobsson, Jan
Nagele, Peter
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Published in British Journal of Anaesthesia. 2019, vol. 122, no. 5, p. 587-604
Abstract Nitrous oxide (N2O) is one of the oldest drugs still in use in medicine. Despite its superior pharmacokinetic properties, controversy remains over its continued use in clinical practice, reflecting in part significant improvements in the pharmacology of other anaesthetic agents and developing awareness of its shortcomings. This narrative review describes current knowledge regarding the clinical use of N2O based on a systematic and critical analysis of the available scientific literature. The pharmacological properties of N2O are reviewed in detail along with current evidence for the indications and contraindications of this drug in specific settings, both in perioperative care and in procedural sedation. Novel potential applications for N2O for the prevention or treatment of chronic pain and depression are also discussed. In view of the available evidence, we recommend that the supply of N2O in hospitals be maintained while encouraging its economic delivery using modern low flow delivery systems. Future research into its potential novel applications in prevention or treatment of chronic conditions should be pursued to better identify its role place in the developing era of precision medicine.
Keywords AnalgesiaObstetrical/methodsAnalgesicsNon-Narcotic/adverse effects/pharmacology/therapeutic useAnesthesiaDental/methodsAnestheticsInhalation/adverse effects/pharmacologyAntidepressive Agents/therapeutic useChronic Pain/prevention & controlConscious Sedation/methodsContraindicationsDrugDepressive DisorderMajor/drug therapyEvidence-Based Medicine/methodsHumansNitrous Oxide/adverse effects/pharmacology/therapeutic use
Identifiers
PMID: 30916011
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Article (Published version) (126 Kb) - public document Free access
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Research group Anesthésie et neurosciences (883)
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BUHRE, Wolfgang et al. European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice. In: British Journal of Anaesthesia, 2019, vol. 122, n° 5, p. 587-604. doi: 10.1016/j.bja.2019.01.023 https://archive-ouverte.unige.ch/unige:137267

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Deposited on : 2020-06-17

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