• Home
  1. Home
  2. Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome
Scientific article
English

Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome

Contributors

Armando, Marco; Ciampoli, Mariasole; Padula, Maria; Amminger, Paul; De Crescenzo, Franco; Maeder, Johanna; Schneider, Maude; Schaer, Marie; Managò, Francesca; Eliez, Stéphan; Papaleo, Francesco

Published in

Neuropharmacology, vol. 168, 107995

Publication date

2020

Abstract

Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients' genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by cognitive dysfunctions and high penetrance of schizophrenia. We first tested the behavioural and cognitive consequences of adolescent exposure to normal or omega-3-enriched diets in wild-type and 22q11DS (LgDel/+) mice. We then contrasted mouse data with those gathered from sixty-two patients with 22q11DS exposed to a normal diet or supplemented with omega-3 during pre-adolescence/adolescence. Adolescent omega-3 exposure had no effects in wild-type mice. However, this treatment ameliorated distractibility deficits revealed in LgDel/+ mice by the Five Choice Serial Reaction Time Task (5CSRTT). The omega-3 improvement in LgDel/+ mice was selective, as no other generalized cognitive and non-cognitive effects were evident. Similarly, omega-3-exposed 22q11DS patients showed long-lasting improvements on distractibility as revealed by the continuous performance test (CPT). Moreover, omega-3-exposed 22q11DS patients showed less risk of developing an Ultra High Risk status and lower conversion rate to psychosis. Our convergent mouse-human findings represent a first analysis on the effects of omega-3 early treatment in 22q11DS. The beneficial effects in attentional control and transition to psychosis could support the early use of omega-3 supplementation in the 22q11DS population.

Keywords

  • Adolescence
  • Translational pharmacology
  • LgDel/+ mutant mice
  • Attention
  • Distractibility

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

ARMANDO, Marco et al. Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome. In: Neuropharmacology, 2020, vol. 168, p. 107995. doi: 10.1016/j.neuropharm.2020.107995

Main files (1)

Article (Published version)

Secondary files (1)

Supplemental data

Identifiers

Additional URL for this publication

https://www.sciencedirect.com/science/article/pii/S0028390820300617

Journal ISSN

0028-3908
517views
3downloads

Technical informations

Creation

18/05/2020 15:40:00

First validation

18/05/2020 15:40:00

Update

23/03/2026 13:07:31

Status update

23/03/2026 13:07:31

Last indexation

01/09/2026 08:21:41
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated