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Title

Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome

Authors
Ciampoli, Mariasole
Amminger, Paul
De Crescenzo, Franco
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Published in Neuropharmacology. 2020, vol. 168, 107995
Abstract Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients' genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by cognitive dysfunctions and high penetrance of schizophrenia. We first tested the behavioural and cognitive consequences of adolescent exposure to normal or omega-3-enriched diets in wild-type and 22q11DS (LgDel/+) mice. We then contrasted mouse data with those gathered from sixty-two patients with 22q11DS exposed to a normal diet or supplemented with omega-3 during pre-adolescence/adolescence. Adolescent omega-3 exposure had no effects in wild-type mice. However, this treatment ameliorated distractibility deficits revealed in LgDel/+ mice by the Five Choice Serial Reaction Time Task (5CSRTT). The omega-3 improvement in LgDel/+ mice was selective, as no other generalized cognitive and non-cognitive effects were evident. Similarly, omega-3-exposed 22q11DS patients showed long-lasting improvements on distractibility as revealed by the continuous performance test (CPT). Moreover, omega-3-exposed 22q11DS patients showed less risk of developing an Ultra High Risk status and lower conversion rate to psychosis. Our convergent mouse-human findings represent a first analysis on the effects of omega-3 early treatment in 22q11DS. The beneficial effects in attentional control and transition to psychosis could support the early use of omega-3 supplementation in the 22q11DS population.
Keywords AdolescenceTranslational pharmacologyLgDel/+ mutant miceAttentionDistractibility
Identifiers
PMID: 32057798
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Other version: https://www.sciencedirect.com/science/article/pii/S0028390820300617
Structures
Research groups Laboratoire d'imagerie et de psychopathologie développementale (693)
NCCR Synapsy
Projects
Swiss National Science Foundation: 324730_144260
Swiss National Science Foundation: 51NF40-158776
Citation
(ISO format)
ARMANDO, Marco et al. Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome. In: Neuropharmacology, 2020, vol. 168, p. 107995. doi: 10.1016/j.neuropharm.2020.107995 https://archive-ouverte.unige.ch/unige:137245

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Deposited on : 2020-06-16

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