Healthcare translation provides a useful and powerful intervention tool to facilitate the engagement with migrants with diverse language, cultural, and health literacy backgrounds. The development of culturally effective and patient-oriented healthcare translation resources has become increasingly pressing. In this chapter, the authors explore, firstly, patient-focused and culturally effective healthcare and medical translation methodologies by integrating insights from health literacy research and corpus-based textual readability evaluation and, secondly, user-oriented criteria which can be used in the development and evaluation of new medical interpreting technologies with a view to enhancing the usability among patients from refugee, migrant, or other socioeconomically disadvantaged populations.