Molecular mechanisms of calcium signaling during phagocytosis

Nunes-Hasler, Paula; Kaba, Mayis; Demaurex, Nicolas

doi:10.1007/978-3-030-40406-2_7

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Title		Molecular mechanisms of calcium signaling during phagocytosis
Authors		Nunes-Hasler, Paula Kaba, Mayis Demaurex, Nicolas
Published in		Hallett, M.B. Molecular and cellular biology of phagocytosis. Cham: Springer. 2020, p. 103-128
Abstract		Calcium (Ca2+) is a ubiquitous second messenger involved in the regulation of numerous cellular functions including vesicular trafficking, cytoskeletal rearrangements and gene transcription. Both global as well as localized Ca2+ signals occur during phagocytosis, although their functional impact on the phagocytic process has been debated. After nearly 40 years of research, a consensus may now be reached that although not strictly required, Ca2+ signals render phagocytic ingestion and phagosome maturation more efficient, and their manipulation make an attractive avenue for therapeutic interventions. In the last decade many efforts have been made to identify the channels and regulators involved in generating and shaping phagocytic Ca2+ signals. While molecules involved in store-operated calcium entry (SOCE) of the STIM and ORAI family have taken center stage, members of the canonical, melastatin, mucolipin and vanilloid transient receptor potential (TRP), as well as purinergic P2X receptor families are now recognized to play significant roles. In this chapter, we review the recent literature on research that has linked specific Ca2+-permeable channels and regulators to phagocytic function. We highlight the fact that lipid mediators are emerging as important regulators of channel gating and that phagosomal ionic homeostasis and Ca2+ release also play essential parts. We predict that improved methodologies for measuring these factors will be critical for future advances in dissecting the intricate biology of this fascinating immune process.
Keywords		Ion channels — Phagocyte — TRPC — TRPM — TRPML — TRPV.
Identifiers		DOI: 10.1007/978-3-030-40406-2_7 PMID: 32399828 ISBN: 978-3-030-40406-2
Full text		Book chapter (Accepted version) (1.4 MB) - Private access Other version: https://link.springer.com/chapter/10.1007%2F978-3-030-40406-2_7
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Mécanismes de la présentation croisée des antigènes (1011) Signaux intracellulaires (210)
Projects		Swiss National Science Foundation: 310030_18909 Swiss National Science Foundation: 310030_189042
Citation (ISO format)		NUNES-HASLER, Paula, KABA, Mayis, DEMAUREX, Nicolas. Molecular mechanisms of calcium signaling during phagocytosis. In: Hallett, M.B. (Ed.). Molecular and cellular biology of phagocytosis. Cham : Springer, 2020. p. 103-128. doi: 10.1007/978-3-030-40406-2_7 https://archive-ouverte.unige.ch/unige:136311